A critical period for antidepressant-induced acceleration of neuronal maturation in adult dentate gyrus
نویسندگان
چکیده
منابع مشابه
Thioperamide-induced Antinociception is Mediated through Endogenous Opioid System in the Dentate Gyrus of Adult Rats
The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...
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The dentate gyrus, an important anatomic structure of the hippocampal formation, is one of the major areas in which neurogenesis takes place in the adult mammalian brain. Neurogenesis in the dentate gyrus is thought to play an important role in hippocampus-dependent learning and memory. Neurogenesis has been reported to be increased in the dentate gyrus of patients with Alzheimer disease, but i...
متن کاملRole of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.
α-Synuclein has been reported to be important in modulating brain plasticity and to be a key protein in neurodegenerative diseases, including Lewy body dementia (LBD). We investigated how α-synuclein levels modulate adult neurogenesis and the development of dendritic arborization and spines in the dentate gyrus, in which new neurons are constantly added. In the human hippocampus, levels of endo...
متن کاملEffects of male phermoneses on neuronal morphology in the dentate gyrus of hippocampus of female Mice
Background & Aims: Neurogenesis in the adult mammal brain occurs throughout life. Adult neurogenesis has been clearly demonstrated in the sub granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. Pheromones that plays an essential role in the development of the central nervous system. The male pheromones are involved in regulating neurogenesis in both the olfactory bulb and hippocam...
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Neural circuits in the dentate gyrus are continuously modified by adult neurogenesis, whose level is affected by the animal's experience. However, it is not known whether this experience-dependent anatomical modification alters the functional properties of the dentate gyrus. Here, using the expression of immediate early gene products, c-fos and Zif268, as indicators of recently activated neuron...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2017
ISSN: 2158-3188
DOI: 10.1038/tp.2017.208